2021-11-23 01:10:55
Case fatality rate: Marburg is one of the deadliest viruses we know of, killing as many as 88% people it infects.
Incubation period: The incubation varies from as short as two days to up to 21 days, though some studies have suggested the virus can incubate for as long as 26 days.
Symptoms: Marburg virus begins with a fever, severe headache and muscle pains. This is often followed by watery diarrhoea, stomach pain, nausea and vomiting, accompanied by extreme exhaustion and lethargy. Many people go on to develop severe viral haemorrhagic fever, and in severe cases have blood in their vomit and faeces, and may bleed from their nose, gums and vagina. The onslaught of the virus is so extreme that most people die 8-9 days after infection, often because of extreme loss of blood.
Diagnosis: Marburg can be difficult to distinguish clinically from other diseases, such as malaria, typhoid fever, meningitis and other viral haemorrhagic fevers. Diagnosis can be confirmed using techniques that detect the presence of immune response to the virus, such as antibody-capture enzyme-linked immunosorbent assay (ELISA), or the presence of virus in people presenting with symptoms, via antigen-capture detection tests, reverse transcriptase polymerase chain reaction (RT-PCR) assay, or virus isolation by cell culture. However, often none of these diagnostic tools are available in the countries with highest risk of Marburg outbreaks. In addition to having the diagnostic tests available, countries need to have laboratories that can ensure maximum biological containment conditions due to the fact that the samples are an extreme biohazard risk. https://www.gavi.org/vaccineswork/next-pandemic/marburg
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